Wayne State University Alzheimer Disease and Abeta Peptides Summary

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I want a summary of Alzheimer Disease that answer all or most of these:

  • 1)Structure and pI of Abeta
  • 2)How Abeta peptides are generated in the brain
  • 3)Chronologic relation between Abeta 42 and 40 generation and the progression of Alzheimer’s disease pathology, vascular dementia, and Down syndrome.
  • 4)The different morphology of mature plaque vs primitive plaque with different Abeta 42 and 40
  • 5)Are bundles present in plaques with Abeta42, Abeta 40 or a mixture of the two kinds of peptides
  • 6)Abeta 42 and 40 amyloid fiber formation pathways
  • 7)Abeta 42 and 40 oligomers size, diameter and number of monomers
  • 8)Abeta 42 and 40 mixture at different ratio and the effect on fiber formation
  • 9)Speculate how abeta 40 may affect Abeta 42 aggregation and formation of oligomers and fibers
  • 10)Speculate how extracelluar matrix such as charged polymers and noncharged polymers affect fiber formation.
  • 11)Guess or Speculate how metal (Copper, Zinc, Calcium) ions such as those found in the plaque affect the fiber formation
  • 12)Speculate how lipid molecules affect fiber formation

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